Unglycosylated recombinant human lymphotoxin polypeptides and compositions
US5683688A · kind A · utility
5Cited by
2References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1992 |
| Grant date | Nov 4, 1997 |
| Priority date | — |
| Expiry date | Feb 14, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biologically active lymphotoxin polypeptides are synthesized in recombinant cell culture. Novel nucleic acid and vectors incorporating same are provided. The compositions and processes herein enable the economical preparation of compositions containing uniform lymphotoxin polypeptides and variant lymphotoxins having amino acid sequences that differ from those found in nature. The lymphotoxins are purified to a specific activity of 2-10.times.10.sup.7 units/mg of protein by purification using a novel immobilized, lymphotoxin-neutralizing monoclonal antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.