Pyrrolopyrimidine derivatives having pharmacological activity
US5686457A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1995 |
| Grant date | Nov 11, 1997 |
| Priority date | — |
| Expiry date | May 3, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the use of the compounds mentioned below in the therapeutic treatment of tumour diseases and other proliferative diseases, such as psoriasis, and to novel compounds of that type. The compounds are compounds of formula I ##STR1## wherein n is from 0 to 5 and, when n is not 0, PA1 R is one or more substituents selected from halogen, alkyl, trifluoromethyl and alkoxy; and PA1 R.sub.1 and R.sub.2 are each independently of the other alkyl, or phenyl that is unsubstituted or substituted by halogen, trifluoromethyl, alkyl or by alkoxy, it also being possible for one of the two radicals R.sub.1 and R.sub.2 to be hydrogen, or R.sub.1 and R.sub.2 together form an alkylene chain having from 2 to 5 carbon atoms that is unsubstituted or substituted by alkyl; or salts thereof. Compounds of formula I inhibit protein kinases, for example the tyrosine protein kinase of the receptor for the epidermal growth factor, EGF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.