Dioxopyrrolo pyrrole derivatives

US5686459A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Francois Diederich · Zürich, CH
• Ulrike Obst · Weil am Rhein, DE
• Sabine Wallbaum · Esslingen am Neckar, DE
• Lutz Weber · Weil am Rhein, DE

Key dates

• Filing date: Feb 26, 1996
• Grant date: Nov 11, 1997
• Expiry date: Feb 26, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel dioxopyrrolo-pyrrole derivatives of the formula ##STR1## as well as hydrates or solvates thereof, which inhibit thrombin-induced or Factor Xa-induced platelet aggregation and fibrinogen clotting in blood plasma. The derivatives can be manufactured from the corresponding maleimides which are N-substituted by .alpha.-amino carboxylic acids of the formula HN(R.sup.2)CH(R.sup.4)COOH, or functional derivatives thereof; and ketones or aldehydes of the formula R.sup.5 C(O)R.sup.6.