Polypeptides having bone resorption inhibitory activity comprising PTHrP-derived sequences

US5688760A · kind A · utility

Assignees

• Genentech, Inc. · US
• The University of Melbourne · AU

Inventors

• Bruce E. Kemp · Melbourne, AU
• Geoffrey Nicholson · Woodbury, US
• Thomas Martin · Konstanz, DE
• Anna J. Fenton · Geelong, AU
• R. Glenn Hammonds · Berkeley, US

Key dates

• Filing date: Aug 12, 1993
• Grant date: Nov 18, 1997
• Expiry date: Aug 12, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polypeptides comprising an N-terminal amino acid sequence corresponding to amino acids 107-111 of parathyroid hormone related protein (PTHrP) having bone resorption inhibitory activity are provided. The polypeptides are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of bone resorption is indicated.