A.sub.3 adenosine receptor agonists

US5688774A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Kenneth A. Jacobson · Silver Spring, US
• Heaok Kim Jeong · Rockville, US
• Suhaib Siddiqi · Raleigh, US
• Carl R. Johnson · Detroit, US
• John A. Secrist, III · Birmingham, US
• Kamal N. Tiwari · Birmingham, US

Key dates

• Filing date: Feb 28, 1995
• Grant date: Nov 18, 1997
• Expiry date: Feb 28, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides A.sub.3 selective agonists, particularly, adenine compounds having selected substituents at the 2, 6, and 9 positions, and related substituted compounds, particularly those containing substituents on the benzyl and/or uronamide groups, as well as pharmaceutical compositions containing such compounds. The present invention also provides a method of selectively activating an A.sub.3 adenosine receptor in a mammal, which method comprises acutely or chronically administering to a mammal in need of selective activation of its A.sub.3 adenosine receptor a therapeutically or prophylactically effective amount of a compound which binds with the A.sub.3 receptor so as to stimulate an A.sub.3 receptor-dependent response.