Recombinant gamma interferons having enhanced stability and methods therefor
US5690925A · kind A · utility
52Cited by
25References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 22, 1994 |
| Grant date | Nov 25, 1997 |
| Priority date | — |
| Expiry date | Mar 22, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N-terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.