O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6

US5691307A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• The Penn State Research Foundation · US
• Arch Development Corporation · US

Inventors

• Robert C. Moschel · Frederick, US
• M. Eileen Dolan · Oak Park, US
• Anthony E. Pegg · Hershey, US
• Mark McDougall · Bethlehem, US
• Mi-Young Chae · Frederick, US

Key dates

• Filing date: Jun 7, 1994
• Grant date: Nov 25, 1997
• Expiry date: Jun 7, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel O.sup.6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O.sup.6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful for treating tumors and when used with anti-neoplastic alkylating agents enhance the chemotherapeutic treatment of tumor cells in a host.