Vasoconstrictive substituted dihydropyranopyridines
US5691344A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 1996 |
| Grant date | Nov 25, 1997 |
| Priority date | — |
| Expiry date | Jan 24, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is concerned with compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, the N-oxides thereof and the stereochemically isomeric forms thereof, wherein .dbd.a.sub.1 --a.sub.2 .dbd.a.sub.3 --a.sub.4 .dbd. is a bivalent radical of formula: EQU .dbd.N--CH.dbd.CH--CH.dbd. (a), EQU .dbd.CH--N.dbd.CH--CH.dbd. (b), EQU .dbd.CH--CH.dbd.N--CH.dbd. (c), EQU .dbd.CH--CH.dbd.CH--N.dbd. (d), wherein in said bivalent radicals one or two hydrogen atoms can be substituted by halo, hydroxy, C.sub.1-6 alkyl or C.sub.1-6 alkyloxy; R.sup.1 is hydrogen or C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is hydrogen or C.sub.1-6 alkyl; Alk.sup.1 is C.sub.1-5 alkanediyl; Alk.sup.2 is C.sub.2-15 alkanediyl; Q is a five- or six-membered heterocyclic ring containing at least one nitrogen atom or a radical of formula ##STR2## wherein R.sup.4 is hydrogen, cyano, aminocarbonyl or C.sub.1-6 alkyl; R.sup.5 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-6 alkynyl; R.sup.6 is hydrogen or C.sub.1-6 alkyl; or R.sup.5 and R.sup.6 taken together may form a bivalent radical of formula --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --. Pha…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.