Polysaccharide-bound nitric oxide-nucleophile adducts

US5691423A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Daniel J. Smith · Manalapan, US
• Debashish Chakravarthy · Vernon Hills, US
• Larry K. Keefer · Bethesda, US

Key dates

• Filing date: Apr 10, 1995
• Grant date: Nov 25, 1997
• Expiry date: Apr 10, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F8/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.