Heterocyclic-substituted alkyl amide acat inhibitors

US5693657A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Helen Tsenwhei Lee · Ann Arbor, US
• Patrick Michael O'Brien · Stockbridge, US
• Joseph Armand Picard · Canton, US
• Claude Forsey Purchase, Jr. · Ann Arbor, US
• Bruce D. Roth · Ann Arbor, US
• Drago R. Sliskovic · Ypsilanti, US
• Andrew White · Ann Arbor, US

Key dates

• Filing date: Jan 21, 1997
• Grant date: Dec 2, 1997
• Expiry date: Jan 21, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 .dbd.R.sub.3 .dbd.H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R.sub.4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.