Methods for synthetic unrandomization of oligomer fragments

US5698391A · kind A · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Phillip Dan Cook · Carlsbad, US
• David J. Ecker · Encinitas, US
• Jacqueline Wyatt · Carlsbad, US
• Thomas W. Bruice · Carlsbad, US
• Kevin P. Anderson · Carlsbad, US
• Ronnie Hanecak · San Clemente, US
• Timothy Vickers · Vista, US
• Peter Davis · Carlsbad, US
• Susan M. Freier · San Diego, US
• Yogesh S. Sanghvi · Encinitas, US
• Vickie Brown-Driver · San Diego, US

Key dates

• Filing date: Dec 16, 1994
• Grant date: Dec 16, 1997
• Expiry date: Dec 16, 2014

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5308
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled oligomers are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.