Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
US5698550A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1993 |
| Grant date | Dec 16, 1997 |
| Priority date | — |
| Expiry date | Jun 14, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## wherein R is an optionally substituted heteroaryl group such as 2-chromanyl, 2-pyridyl or 5-fluoro-2-benzothiazoyl; PA1 X is O, S or (CH.sub.2).sub.m ; PA1 R.sup.1 is phenyl or pyridyl, optionally substituted by one or more (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy, carboxy or (C.sub.1 -C.sub.3)alkoxy!carbonyl groups; PA1 n is 0, 1 or 2; PA1 m is 1 or 2; PA1 Y and Y.sup.1 are taken together and are oxygen, or Y and Y.sup.1 are taken separately, Y is hydrogen and Y.sup.1 is hydroxy or an in vivo hydrolyzable acyloxy group; PA1 Z is CH.sub.2, NR.sup.2, O or S; and PA1 R.sup.2 is hydrogen or (C.sub.1 -C.sub.3)alkyl; are useful in the treatment of asthma, arthritis and related diseases mediated by leukotrienes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.