PNA-DNA-PNA chimeric macromolecules
US5700922A · kind A · utility
397Cited by
5References
23Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 24, 1993 |
| Grant date | Dec 23, 1997 |
| Priority date | — |
| Expiry date | Nov 24, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2525/125
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Macromolecules are provided that have increased nuclease resistance, increasing binding affinity to a complementary strand, and that activate RNase H enzyme. The macromolecules have the structure PNA-DNA-PNA where the DNA portion is composed of subunits of 2'-deoxy-erythro-pentofuranosyl nucleotides and the PNA portions are composed of subunits of peptide nucleic acids. Such macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.