Glycolipid enzyme-polymer conjugates

US5705153A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Robert Shorr · Edison, US
• Carl W. Gilbert · Berkeley Heights, US
• Brian M. Martin · Rockville, US
• Myung-Ok Cho · Highland Park, US
• Edward J. Ginns · Bethesda, US

Key dates

• Filing date: Oct 23, 1996
• Grant date: Jan 6, 1998
• Expiry date: Oct 23, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.