Adenosine deaminase inhibitor
US5705491A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 27, 1993 |
| Grant date | Jan 6, 1998 |
| Priority date | — |
| Expiry date | Oct 27, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to adenosine deaminase inhibitors containing at least one O-alkylated moiety and the pharmaceutically acceptable salts thereof. The pharmaceutical compositions of the present invention include adenosine deaminase inhibitors containing at least one of the compounds represented by Formula (I): ##STR1## wherein each of R.sub.1, R.sub.2, and R.sub.3 are the same or different and is hydrogen or alkyl; PA1 R is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkynyl, alkoxy, phenyl, hydroxy, amino, alkylamino, phenylamino or halogen; PA1 X is hydrogen, alkyl, alkynyl, allyl, methallyl, cycloalkyl, alkyl having one or more hydroxy groups, phenyl, substituted phenyl, alkyl having one or more phenyl groups, alkyl having one or more substituted phenyl groups, bicycloalkyl, naphthylalkyl, acenaphthylenylalkyl or a compound represented by Formula (II) or Formula (III) ##STR2## wherein Z is hydrogen, hydroxy or lower alkoxy; Q is hydrogen or hydroxy; PA1 A is --CH.sub.2 --, --O--, --S-- or a mere linkage; PA1 Y is (CH.sub.2).sub.n -- or a mere linkage; PA1 n is an integer from 1 to 3; and PA1 any of R.sub.1, R.sub.2, and R.sub.3 is R.sub.3 lower alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.