Combination of necrosis-inducing substances with substances which are activated by necroses for the selective therapy of tumors and inflammatory disorders

US5710134A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Klaus Bosslet · Marburg, DE
• Jorg Czech · Marburg, DE
• Dieter Hoffmann · Marburg, DE

Key dates

• Filing date: May 19, 1995
• Grant date: Jan 20, 1998
• Expiry date: May 19, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a combination of substances (component I) inducing necrosis in tumors or inflamed tissue with other nontoxic substances ("prodrugs", component II). The enzymes set free by necrotic processes then cleave the nontoxic "prodrug" into the toxic "drug", which leads to massive tumor cell death and/or remission of inflammation.