Compositions of tricyclic .beta.-lactams and uses thereof
US5712268A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1995 |
| Grant date | Jan 27, 1998 |
| Priority date | — |
| Expiry date | Apr 12, 2015 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J8/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are described pharmaceutical compositions comprising PA1 (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an .alpha.- or .beta.-amino acid or a residue of the general formula EQU Q--X--Y-- (a) PA1 wherein Q signifies a 3- to 6-membered ring which optionally contains nitrogen, sulphur and/or oxygen and which is optionally bonded with a fused ring, X signifies a direct bond or a linear "spacer" with up to 6 atoms consisting of carbon, nitrogen, oxygen and/or sulphur, of which up to 2 atoms can be nitrogen atoms and 1 atom can be oxygen or sulphur, and Y represents one of the groups --CO--, --CS--, --CONH-- and (where X contains neither sulphur nor carbonyl as a terminal component) --SO.sub.2 --; and in which R.sup.1 and R.sup.2 together signify a group of the formula ##STR2## wherein A represents hydrogen or a residue which is usable in the 3-position of cephalosporin antibiotics, and in which R.sub.3 represents hydrogen, or their pharmaceutically compatible salts; and PA1 (b) a therapeutically effective amount of a .beta.-lactam antibiotic or their pharmaceutically compatible salts; PA1 and a pharm…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.