Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs

US5714511A · kind A · utility

Assignees

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US
• UNIVERSITY OF PITTSBURGH · US

Inventors

• Joseph E. Saavedra · Thurmont, US
• Larry K. Keefer · Bethesda, US
• Timothy Billiar · Pittsburgh, US

Key dates

• Filing date: Jul 31, 1995
• Grant date: Feb 3, 1998
• Expiry date: Jul 31, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/495
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tissue from sepsis- or shock-induced injury.