Use of carbocation scavenger during oligonucleotide synthesis
US5714597A · kind A · utility
11Cited by
12References
8Claims
0Family size
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Key dates
| Filing date | Mar 8, 1996 |
| Grant date | Feb 3, 1998 |
| Priority date | — |
| Expiry date | Mar 8, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.