Integrated nucleic acid analysis system for MALDI-TOF MS
US5716825A · kind A · utility
397Cited by
10References
19Claims
0Family size
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Key dates
| Filing date | Nov 1, 1995 |
| Grant date | Feb 10, 1998 |
| Priority date | — |
| Expiry date | Nov 1, 2015 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00961
- WIPO fieldElectrical machinery, apparatus, energy
- WIPO sectorElectrical engineering
Abstract
An integrated nucleic acid sample analysis system for matrix-assisted laser-desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) is described. The integrated system comprises a miniaturized sample preparation compartment interfaced directly with a MALDI-TOF ionization surface for amplifying and/or otherwise chemically manipulating an oligonucleotide analyte and presenting the analyte to a MALDI ionization surface for mass spectrometry analysis. The miniaturized integrated sample handling system disclosed herein finds application in the amplification and analysis of DNA samples for genetic diagnosis and other uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.