In vivo tumor detection assay
US5720937A · kind A · utility
112Cited by
8References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 28, 1994 |
| Grant date | Feb 24, 1998 |
| Priority date | — |
| Expiry date | Nov 28, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In vivo assay methods for detecting tumors having amplified expression of the HER2 receptor are disclosed. In the assay, cells within the body of a mammal are exposed to an antibody which specifically binds to the extracellular domain of the HER2 receptor and inhibits growth in vitro of SK-BR-3 breast tumor cells which overexpress p185.sup.HER2. The antibody is generally tagged with a radioactive isotope to permit the extent of binding of the antibody to the cells to be quantified.
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