Chemical linkage of ribozyme protions
US5728818A · kind A · utility
7Cited by
2References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1996 |
| Grant date | Mar 17, 1998 |
| Priority date | — |
| Expiry date | Jan 16, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/121
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Method for synthesis of an enzymatic nucleic acid by providing a 3' and a 5' portion of the enzymatic nucleic acid having independent chemically reactive groups at the 5' and 3' positions, respectively, under conditions in which a covalent bond is formed between the 3' and 5' portions by the chemically reactive groups. The bond is selected from the group consisting of, disulfide, morpholino, amide, ether, thioether, amine, a double bond, sulfonamide, ester, carbonate, and hydrazone. The bond is not the natural bond formed between a 5' phosphate group and a 3' hydroxyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.