Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5736336A · kind A · utility
109Cited by
3References
20Claims
0Family size
Inventors
Key dates
| Filing date | May 1, 1997 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | May 1, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.