Envelope fusion vectors for use in gene delivery
US5736387A · kind A · utility
34Cited by
0References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 1, 1994 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | Jun 1, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/13043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides retroviral vectors which can be used for directing gene delivery to a specific sub-population of mammalian cells. The vectors comprise chimeric targeting proteins which specifically alter the host range of the vector. The chimeric targeting proteins contain a ligand moiety which is capable of binding to receptors present on target cells, and an uptake moiety which is capable of promoting entry of the vector into the target cell. The ligand moiety is derived from a cytokine that acts upon the target cells of interest, and the uptake moiety is derived from a retroviral envelope protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.