Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for CNS disorders

US5739158A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Brian R. de Costa · Rockville, US
• Kenner C. Rice · Bethesda, US
• Nancy M. Gray · Ellisville, US
• Patricia C. Contreras · West Chester, US
• Arthur E. Jacobson · Rockville, US
• Andrew Thurkauf · Danbury, US
• Lilian A. Radesca · Newark, US
• Wayne Bowen · Derwood, US
• J. Michael Walker · Providence, US

Key dates

• Filing date: Jul 1, 1992
• Grant date: Apr 14, 1998
• Expiry date: Jul 1, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychotic disorders, convulsions and parkinsonism. Compounds of particular interest are of the formula ##STR1## wherein R.sup.1 is selected from hydrido, loweralkyl, cycloalkylalkyl of four to six carbon atoms and loweralkenylloweralkyl; wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and loweralkyl; wherein each of R.sup.4 through R.sup.7, R.sup.10 and R.sup.11 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein n is a number selected from four through six; wherein p is a number selected from zero through four; wherein q is a number selected from three through five; wherein A is selected from phenyl, naphthyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.