Preparation of sodium chloride aerosol formulations
US5747002A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 5, 1995 |
| Grant date | May 5, 1998 |
| Priority date | — |
| Expiry date | Apr 5, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein is a method for the preparation of sodium chloride formulations having a substantially uniform particle size suitable to ensure the dispersible properties for inhalation into the lungs of a subject. The formulations thus prepared are also the subject of this disclosure. The method involves jet milling coarse sodium chloride in one or preferably two or more procedures using air pressure suitable to produce particles having a significant fraction that are less than about 7 microns in size. Immediately following the milling, the particles are vacuum dried in an oven using a temperature and time suitable to cure the product to prevent substantial aggregation over time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.