C-4' modified adenosine kinase inhibitors
US5763596A · kind A · utility
101Cited by
3References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1996 |
| Grant date | Jun 9, 1998 |
| Priority date | — |
| Expiry date | Jun 7, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to adenosine kinase inhibitors and to nucleoside analogs, C-4' modified pyrrolo2,3-d!pyrimidine and pyrazolo3,4-d!pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention relates to nucleoside analogs of this kind, having zero substitutions or two substitutions at the C-4' position of the furanose (sugar) moiety. The invention also relates to the preparation and use of these adenosine kinase inhibitors in the treatment of cardiovascular, and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.