Monomeric naphthylisoquinoline alkaloids and synthesis methods thereof

US5763613A · kind A · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Gerhard Bringmann · Würzburg, DE
• Roland Götz · Ludwigshafen, DE
• Michael R. Boyd · Mobile, US

Key dates

• Filing date: Jul 1, 1996
• Grant date: Jun 9, 1998
• Expiry date: Jul 1, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and other monomeric naphthylisoquinoline alkaloids. The invention also provides new, medically useful naphthylisoquinoline compounds and derivatives thereof.