Modified antibody variable domains
US5766886A · kind A · utility
431Cited by
10References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 13, 1993 |
| Grant date | Jun 16, 1998 |
| Priority date | — |
| Expiry date | Aug 13, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.