Comformationally constrained backbone cyclized somatostatin analogs

US5770687A · kind A · utility

Assignees

• Peptor Ltd. · IL
• Yissim Research Development Co. of Hebrew University of Jerusalem · IL

Inventors

• Vered Hornik · Rehovot, IL
• Alon Seri-Levy · Jerusalem, IL
• Gary Gellerman · Rishon LeZion, IL
• Chaim Gilon · Jerusalem, IL

Key dates

• Filing date: Jul 31, 1996
• Grant date: Jun 23, 1998
• Expiry date: Jul 31, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel peptide analogs are disclosed. The novel peptides are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions in the treatment of endocrine disorders, neoplasms and metabolic disorders are also disclosed.