Systematic evolution of ligands by exponential enrichment: chimeric selex
US5773598A · kind A · utility
91Cited by
1References
5Claims
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Key dates
| Filing date | Jun 5, 1995 |
| Grant date | Jun 30, 1998 |
| Priority date | — |
| Expiry date | Jun 5, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/976
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are disclosed for producing chimeric nucleic acid molecules with two or more functionalities. A chimeric library is generated in which individual chimeric molecules combine the functions or characteristics of two or more parent libraries, each parent library having been selected through the SELEX procedure for a specific function or feature. The chimeric molecules of this invention are useful in a variety of ways, including having improved affinities for a target molecule, enhancing assembly of multi-component molecules, and promoting reactions between two molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.