DNA fragments obtained from a novel human immunodeficiency virus designated LAV.sub.MAL
US5773602A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 18, 1993 |
| Grant date | Jun 30, 1998 |
| Priority date | — |
| Expiry date | Nov 18, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16051
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel human immunodeficiency virus type 1 (HIV-1) isolate, designated lymphadenopathy-associated virus strain MAL, or LAV.sub.MAL, was molecularly cloned and characterized. Nucleotide sequence analysis demonstrated that the viral genome of LAV.sub.MAL is 9229 nucleotides long. This retrovirus contains the canonical gag, pol, and env genes, as well as ancillary genes encoding Vif (or Q), Vpr (or R), Tat (or S), and Nef (or F). This virus differs significantly, at both the nucleotide and amino acid sequence levels, from prototypical HIV isolates (e.g., HTLV-III, LAV.sub.BRU, and ARV). DNA fragments corresponding to the various gene products and regulatory regions are disclosed. These fragments are useful, inter alia, as probes in diagnostic assays and for the generation of recombinant proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.