Heteroatomic oligonucleoside linkages
US5777092A · kind A · utility
37Cited by
1References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 4, 1997 |
| Grant date | Jul 7, 1998 |
| Priority date | — |
| Expiry date | Feb 4, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.