Chemical synthesis of 1,3-disubstituted quinazolinediones
US5783698A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 7, 1997 |
| Grant date | Jul 21, 1998 |
| Priority date | — |
| Expiry date | Jan 7, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/96
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method for the synthesis of 1,3-disubstituted quinazolinedione derivatives which comprises: PA1 (a) reacting a haloformate functionalized polystyrene resin with a substituted anthranilic acid derivative under conditions effective to form a urethane-linkage; PA1 (b) reacting the product of step (a) with a primary amine under conditions effective to form an anthranilamide derivative; PA1 (c) heating the anthranilamide to effect intramolecular cyclization thereby liberating the 1,3-disubstituted quinazolinedione derivative from the resin into solution; and PA1 (d) isolating the 1,3-disubstituted quinazolinedione by filtration and solvent removal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.