Method for loading lipid vesicles
US5785987A · kind A · utility
83Cited by
0References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1996 |
| Grant date | Jul 28, 1998 |
| Priority date | — |
| Expiry date | Feb 27, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1278
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for the preparation of stable liposome formulations of protonatable therapeutic agents. The methods involve loading a therapeutic agent into preformed liposomes having a methylamine concentration gradient across the lipid bilayer of the liposomes. These methods provide liposome formulations which are more stable, more cost effective, and easier to prepare in a clinical environment than those previously available. The present invention also provides the pharmaceutical compositions prepared by the above methods, a kit for the preparation of liposome formulations of therapeutic agents, and methods for their use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.