Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1

US5786322A · kind A · utility

Assignee

• Affymax Technologies N.V. · NL

Inventors

• Ronald W. Barrett · Saratoga, US
• Steven E. Cwirla · Menlo Park, US
• William J. Dower · Menlo Park, US
• Kerry J. Koller · San Francisco, US
• Jung Lee · Mountain View, US
• Christine L. Martens · Portola Valley, US
• Beatrice Ruhland-Fritsch · Mountain View, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jul 28, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.