Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders, acute liver disorders and the complications associated therewith

US5786365A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Holger Heitsch · Hofheim, DE
• Adalbert Wagner · Gersthofen, DE
• Klaus Wirth · Frankfurt am Main, DE
• Max Hropot · Flörsheim, DE
• Martin Bickel · Frankfurt am Main, DE

Key dates

• Filing date: May 19, 1997
• Grant date: Jul 28, 1998
• Expiry date: May 19, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of nonpeptide bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders (hepatic cirrhosis and hepatic fibrosis), acute liver disorders and for the prevention of complications, in particular for the prophylaxis or treatment of portal hypertension, decompensation symptoms such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.