Dimeric arylisoquinoline alkaloids and synthesis method thereof

US5786482A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• The Trustees of Boston College · US

Inventors

• Gerhard Bringmann · Würzburg, DE
• Michael R. Boyd · Mobile, US
• Roland Götz · Ludwigshafen, DE
• T. Ross Kelly · Watertown, US

Key dates

• Filing date: Sep 24, 1996
• Grant date: Jul 28, 1998
• Expiry date: Sep 24, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a method of preparing dimeric arylisoquinoline alkaloids by coupling two isoquinoline building blocks, which may be the same or different, together with a symmetrical or nonsymmetrical biaryl building block to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric arylisoquinoline compounds and derivatives thereof.