Nitric oxide releasing compounds as protective agents in ischemia reperfusion injury

US5789447A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• David A. Wink · Hagerstown, US
• James B. Mitchell · Damascus, US
• Angelo Russo · Bethesda, US
• Murali C. Krishna · Derwood, US
• Ingeborg Hanbauer · Bethesda, US
• Matthew B. Grisham · Shreveport, US
• Daniel Neil Granger · Shreveport, US

Key dates

• Filing date: Sep 12, 1995
• Grant date: Aug 4, 1998
• Expiry date: Sep 12, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.