Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof

US5789594A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Gerhard Bringmann · Würzburg, DE
• Sven Harmsen · Würzburg, DE
• Michael R. Boyd · Mobile, US

Key dates

• Filing date: Jul 1, 1996
• Grant date: Aug 4, 1998
• Expiry date: Jul 1, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8' to C-5 naphthalene/isoquinoline linkage, to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric naphthylisoquinoline compounds and derivatives thereof.