High level expression of proteins

US5795737A · kind A · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Brian Seed · Boston, US
• Jurgen Haas · Schriesheim, DE

Key dates

• Filing date: Sep 22, 1995
• Grant date: Aug 18, 1998
• Expiry date: Sep 22, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16122
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention features a synthetic gene encoding a protein normally expressed in a mammalian cell or eukaryotic cell wherein at least one non-preferred or less preferred codon in the natural gene encoding the mammalian protein has been replaced by a preferred codon encoding the same amino acid.