Nucleotide analogs
US5798340A · kind A · utility
82Cited by
19References
41Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 1996 |
| Grant date | Aug 25, 1998 |
| Priority date | — |
| Expiry date | May 6, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nucleotide analogs characterized by the presence of an amidate lirked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.