Isolation, characterization, and use of the human and subunit of the high affinity receptor for immunoglobulin E
US5807988A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1994 |
| Grant date | Sep 15, 1998 |
| Priority date | — |
| Expiry date | Feb 24, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to nucleic acid sequences, encoding amino acid sequences of the .beta., and subunit of the human high affinity receptor for immunoglobulin E, and for amino acid sequences of the subunit. A segment of the amino acid sequence containing an antigen recognition activation motif (ARAM) that exhibits different functions than other ARAMS, including that of the ARAM-.gamma. subunit of Fc.epsilon.RI. The invention further relates to a method of producing the receptor by expressing cDNA for its a, .beta., and .gamma. subunits in a host cell simultaneously. Aspects of the invention are methods and compositions to inhibit the function of the human beta subunit, thereby treating or preventing allergic reactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.