Indole derivatives as dopamine D4 antagonists
US5814644A · kind A · utility
7Cited by
4References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 8, 1996 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Apr 8, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compound of formula (I), or a pharmaceutically acceptable salt thereof or a prodrug thereof wherein E represents --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --; R represents hydrogen or C.sub.1-6 alkyl; Q represents a moiety of formula Qa, Qb, Qc or Qd which are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D.sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.