Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen
US5821223A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 1994 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | May 5, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/193
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a potent mitogenic growth factor called plasminogen-like growth factor (PLGF) isolated from conditioned medium of human lung fibroblasts. The protein has an apparent molecular weight under reducing conditions of 87 kDa and is structurally related to hepatocyte growth factor (HGF); however unlike HGF, which was reported to be specific for hepatic cells, PLGF stimulates a wide spectrum of target cells including melanocytes, endothelial cells and epithelial cells but excludes fibroblast cells. The present invention further relates to recombinant cloned DNA fragments and expression cell systems expressing biologically active PLGF. The availability of purified PLGF as well as immunological and molecular probes should facilitate the study of proliferative disorders in which the factor plays an important role.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.