Methods of administering peptides that bind to the erythropoietin receptor

US5830851A · kind A · utility

Assignee

• Affymax Technologies N.V. · NL

Inventors

• Nicholas Wrighton · Palo Alto, US
• William J. Dower · Menlo Park, US
• Ray S. Chang · Colma, US
• Arun K. Kashyap · Newark, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Nov 3, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of 10 to 40 or more amino acid residues in length and having the sequence X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X.sub.3 is C; X.sub.4 is R, H, L, or W; X.sub.5 is M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids; X.sub.7 is D, E, I, L, or V; and X.sub.8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.