Purification of recombinant human IL-1.alpha.
US5831022A · kind A · utility
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7Claims
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Key dates
| Filing date | Feb 18, 1986 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Feb 18, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/141
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the production of essentially homogeneous soluble, stable, endotoxin free human recombinant interleukin-1.alpha. of enhanced specific activity is described. The process involves breaking transformed microbial cells containing expressed human interleukin-1.alpha. and separating the soluble supernatant from the insoluble cell components and then passing the supernatant through gel chromatography and ion-exchange chromatography steps.
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