Synthesis deprotection analysis and purification of RNA and ribozymes
US5831071A · kind A · utility
53Cited by
7References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 29, 1997 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Aug 29, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for deprotecting RNA 2'-O-alkylsilyl groups comprising, contacting the groups with a solution of anhydrous triethylamine-hydrogen fluoride (aHF-TEA) in triethylamine and N-methylpyrrolidine at between 60.degree. C.-70.degree. C. for 0.25-24 h.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.