Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use

US5834500A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Adalbert Wagner · Gersthofen, DE
• Holger Heitsch · Hofheim, DE
• Gerhard Nolken · Pocking, DE
• Klaus Wirth · Frankfurt am Main, DE
• Bernward Scholkens · Kelkheim, DE

Key dates

• Filing date: May 16, 1997
• Grant date: Nov 10, 1998
• Expiry date: May 16, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/64
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use Compounds of the formula (I) ##STR1## in which one of the radicals X.sub.1, X.sub.2 or X.sub.3 is C--O--R.sup.2 and the other X.sub.1, X.sub.2, and X.sub.3, in each case, and X.sub.4, are then, identically or differently, N or CR.sup.1 ; R.sup.1 and R.sup.3 are, identically or differently, H, halogen, (C.sub.1 -C.sub.6)-alkyl, O--R.sup.6, S--R.sup.6, NHR.sup.6, (C.sub.6 -C.sub.12)-aryl, (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.3)-alkyl, C(O)--OR.sup.6, C(O)--H, (C.sub.2 -C.sub.5)-alkenyl, NO.sub.2, SO.sub.3 R.sup.7, CN or C(O)--NHR.sup.8, where alkyl, aryl and alkenyl can optionally be substituted.