Sulphonamides

US5837708A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Volker Breu · Schliengen, DE
• Kaspar Burri · Binningen, CH
• Jean-Marie Cassal · Mulhouse, FR
• Martine Clozel · Binningen, CH
• Georges Hirth · Colmar, FR
• Bernd-Michael Loffler · Oberrimsingen, DE
• Marcel Muller · Frenkendorf, CH
• Werner Neidhart · Hagenthal-le-Bas, FR
• Henri Ramuz · Birsfelden, CH

Key dates

• Filing date: Oct 15, 1996
• Grant date: Nov 17, 1998
• Expiry date: Oct 15, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.